Background:
@EN Mivacurium is a nondepolarizing muscle relaxant and metabolized by pseudocholinesterase(pChe). Many reports show fall in pChe activity during pregnancy so the metabolism of mivacurium may be delayed and muscle relaxation would be prolonged.
@ES Methods:
@EN Muscle relaxation of full-term pregnant women(C group, n=10) and nopregnant women(Non-C group, n=10) was maintained by continuous infusion of mivacurium to keep lst response of TOF at 5±1%. After discontinuance of infusion, recovery profiles
were
measured with accelerography.
@ES Results:
@EN The Infusion rate of mivacurium to maintain 1st twich response of TOF at 5±1% was significantly low in C group comparing with Non-C group(P<0.05). There was no significant difference in pChe activity between two group. There was no
significant
difference in recovery index, recovery time(T1 25%-T4 ratio, 0.75). There was a little correlation between the total infusion time and recovery profiles(recovery index: r*=0.37, recvery time: r*=0.28). Strong correlation existed between
bolus-T5(time
interval from the injection of mivacurium to recovery of 5% twitch hight) and infusion rate(r*=0.76).
@ES Conclusion:
@EN The mivacurium infusion rate of C group to maintain muscle relaxation was significantly lower than Non-C group. There would be many possible including over-estimation of paturient body weight compared with lean body mass, decrease of blood
volume
due to hemorrhage. (Korean J Anesthesiol 1996: 198~205).
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